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Monday, February 07, 2005

 Update on Dave Eastman
 
Hello everyone,

Many have been waiting for the nine-month update on David Eastman, the fellow who was told he would be dead from his glioblastoma brain tumor in 12 months. As you will see, his health is the envy of most of the people who meet him. In fact, a friend whom he has known for a lot of years met Dave the other day, and not having seen him for quite a while, could not believe he could be so well!


Enjoy the story. Share it as widely as you wish/can. Just keep in mind that it cannot be used to promote any company or commercial products. That's why no mention is being made of any company or products anywhere in this e-mail. When you share the story in any form you must do the same. (What you say verbally is your own concern, if you know what I mean.)

This is going out to hundreds of people, who in turn will forward it. Dave and Deb don't mind answering enquiries from those with serious health challenges, but please protect them from being inundated with phone calls. Thank you for being considerate of them. The most important information is the protocol of Dr. Reg McDaniel's protocol (below).

Eugene


PS Expect a further update when Dave has completed his first year, in April '05.


 

MY RECOVERY FROM CANCER

By David Eastman

(As told to Eugene)

Hello,

My name is David Eastman. I am enjoying a great recovery from a deadly glioblastoma brain tumor. It's 'medically impossible,' but it's actually happening, and I want to share the reason with the whole world.

Nine months ago I was told I had only 12 months to live, yet a few days ago my oncologist reported that I am in total recovery, in great general health and there's no sign of cancer anywhere in my body! My six month report was excellent, but this one is even better. I'm not greatly surprised, but I sure am delighted! My oncologist is, too. Cancer people don't get to deal with many success stories.

I feel healthier than any time in my entire life. My body has actually gone through a total renewal and I have a whole new outlook on life. I am grateful to God for excellent medical care, but I am extremely grateful for the gift of glyconutritionals* that make all the difference. I am very healthy and very, very happy. And now I am reaching out to others.

My wife, Deborah, and I live near the village of Arkona, in Southwestern Ontario, Canada. I'm 47 and a building contractor by trade. I've always enjoyed work and have rarely been sick. I'm back to working as hard as ever, but my focus has shifted. Deb and I are trying to introduce glyconutritionals to everyone, knowing everyone needs them. We especially try to reach cancer people. And we're succeeding!

A whole new chapter in my life began in 1997 when good friends Eugene and Gloria Fox told Deb and me about some natural supplements they were taking. I was somewhat interested, but it got Deb's attention because of her severe allergies. So we registered to receive the products, and they really worked! Deb was soon much better and never wanted to be without the products. As for me, I was convinced I was healthy so I hardly touched them. That was almost a fatal mistake! Now I know that feeling healthy doesn't have much to do with whether you are really well. That can be very misleading and it certainly fooled me.

Everything changed in the spring of 2004 when I was struck down by terrible headaches and then diagnosed with a glioblastoma brain tumor. The cancer expert told Deb, "It will kill him. In spite of all we can do the tumor will grow back -- and he will die within 12 months. This will happen." He was so sure because no one escapes that kind of brain tumor. Just about everyone dies within 12 months. I'm told it's as lethal as pancreatic cancer.

The surgeon said he would remove as much of the tumor as possible, but didn't expect to get it all. That's because the roots went right into my brain. Trying to get it all would have killed me. The surgery was performed in London, Ontario, Canada, a world-class medical and research center.

Deb and I put everything in the hands of the Lord, along with our praying friends. I was not afraid because the Lord is very real to us and has seen us through many problems, with this being just one more. It also helped that for seven years we learned how very effective glyconutritionals are.

When I came out of the anesthetic the Lord almost spoke audibly to me: "Eugene and Gloria will come alongside you." We soon found out what that meant. They introduced us to the cancer protocol of Dr. Reg McDaniel, a pioneer in glyconutritional technology who has been working with it for the last 20 years. I got on the protocol right away and intend to stay on it for the five years recommended by Dr. Reg.

A hero of ours is Dr. Rayburne Goen, M.D., who discovered glyconutritionals at age 85, after 60 years of medical practice. He says, "Without an adequate supply of these vital nutrients the body is dysfunctional, sick, dying or dead." Exactly right.

We will share this technology that saved my life with anyone. It can open up a quality of life most of us never thought possible, the quality of life we are enjoying.

We're planning a big celebration after I complete what was supposed to be the last year of my life, completing it in great health. We'll announce the details later.

 

Summary of My Experience

The first sign that something was wrong was a series of very severe headaches. By 25 March, 2004 Dave needed to take large quantities of Tylenol. Here are the subsequent events:

April 8/04 - Dave had a very difficult day at work. By evening he could not feed himself and could not chew food. He couldn't so much as hold a glass of water. Light made his eyes hurt.

April 10/04 - Dave's right ear pained and seemed to be infected. Later it was learned that the tumor was putting pressure on that area.


April 12/04- A CAT scan revealed the massive brain tumor.

April 15/04 - Dave had an MRI (Magnetic Resonance Image). The tumor measured 6.5 cm X 5 cm (2.5" X 2"). That's huge!

April 16/04 - Emergency surgery for 4 1/2 hours. Dave and Deb had been cautioned that the outcome could be paralysis, loss of vision, a stroke, even death.

To give Dave the best chance of a good outcome Deb had fed him large amounts of glyconutrients (the complex of eight functional sugars listed in the medical text Harper's Biochemistry, 26th edition, Murray et al). She avoided difficulties of giving something to Dave by just 'not bothering' to tell the hospital staff. She's a nurse so it worked. That gave Dave excellent nutritional support.

The day after the surgery Dave was sitting on the side of his bed, waiting for breakfast, instead of being totally bedridden as expected. Later, he went for a walk with his twin brother, Don.

The surgeon told Dave he had been able to remove more of the tumor than expected. There were, however, vision problems caused by the tumor. Dave was told he would never drive again. On 3 June, part of his remarkable recovery was being cleared to drive again, one month after surgery!

April 19/04 - Two days after surgery Dave was discharged from hospital and went home. He was told he could have been released the previous day! Prior to the surgery he was told he would be hospitalized for weeks.

Two doctors remarked on the rapid healing of the incision, which is now just a fine line. Deborah helped this healing with repeated applications of a highly concentrated glyconutritional jell.


May 5/04 - Dave began radiation therapy as an outpatient. He also began taking a very toxic chemotherapy agent. He received the radiation five days a week, until 17 June. He was never sick! The pharmacist dispensing the chemotherapy drug was amazed. Knowing how very toxic the drug was, he phoned the Eastmans to check on Dave. He could hardly believe what he heard. Cooking smells bothered him a bit, but that was all. (After the nine-month examination the chemotherapy was discontinued.)

Through his sickness Dave lost 15 pounds. Being quite slim already, this was serious. Soon after the surgery, in spite of the radiation and chemotherapy, he developed a ravenous appetite, and quickly regained the lost weight. He says that for a while he "ate all day long," gaining about a pound a day! He soon looked the picture of health, and still does.

Dave and Deb had been cautioned that the chemotherapy would drastically affect Dave's immune system, requiring them to do everything possible to avoid him becoming sick. But not long after coming home others in the household became sick. Dave did not. The reason was soon evident. His blood work, done every week, showed his immune system as completely normal throughout his entire recovery. A doctor remarked, "You have a very strong immune system!" Dave and Deb just nodded and smiled.

All Dave's vital signs have been consistently excellent, in spite of the radiation and chemotherapy. Surely this is only attributable to the support of the glyconutritionals.

May 11/04 - Dave bicycled 2 1/2 miles to town to visit his mother. He experienced no particular tiredness.

May 13/04 - Dave walked to town at a casual pace, enjoying the exercise. He also did what he calls 'power walks'.

May 31/04 - Dave discovered that his chronic (and quite severe) gluten allergy had cleared up! He accidentally ate several muffins made with wheat flour with no reaction. Previously he would break out with serious skin problems if he ate anything containing gluten. A mild problem with gluten has since returned.

June 6/04 - A community benefit dinner was held for the Eastman's, attended by 250 friends and family members. It raised over $4,000. In his response Dave said, "I've never felt better in my life!"

June 17/04 - CAT scan showed no evidence of the tumor.

June 18/04 - Dave and Deb attended a family wedding and reception. Dave experienced no particular weariness.

June 29/04 - Dave has always been active and used to hard work so he became bored and went back to work. His first project? Building a concrete block wall! He had none of his old back problems. He worked full days, getting normally tired at the end of the day, but that's all.

July 7/04 - MRI showed no sign of any tumor. (Please remember, the Eastmans had been told emphatically that the tumor would grow back and kill him in 12 months. But there was no evidence of anything of the sort.)

July 9/04 - Deb and others had been concerned about Dave's 'vacant stare,' even though he was mentally alert. On this day it ceased and has not returned. He has rapidly regained any lost mental acuity and is now reading voraciously.


At the time Deborah's comment was, "All Dave's deficits were minor."

Dave and Deb want everyone to know that they are convinced it's the science-based glyconutritional technology that has restored Dave's health, along with the radiation and chemotherapy, with everything supported by much prayer.

October 22/04 - Follow-up MRI indicated everything is better than ever. No sign of the tumor. Dave's blood work continued totally normal. Every indication of continued very good health.
Dave continuing with the glyconutritional protocol and also the chemotherapy. Blood work now reduced to twice per month, with follow-up MRIs to come at 9 month and 12 months after surgery.
  What is discussed here is very advanced nutritional science --Glycobiology. Understandably, it is rapidly becoming obvious that it is the hope of modern health care. MIT (Massachusetts Institute of Technology) thoroughly examined it and has publicly affirmed that this approach to wellness will change the entire world as we now know it.

Dave enjoying working full days, doing physically demanding work. Nothing but a steady, sustained recovery to full, robust health. Outlook very positive.

This is anything but unique. Numerous others have followed this integrative approach to wellness with similar excellent outcomes. Some are now cancer-free for 18 years. Recent research indicates that a trillion or more adult stem cells are generated by a person's own bone marrow when supported by the glyconutrients. These cells contribute to the restoration of the body, including the brain. This likely explains the remarkable recoveries enjoyed by Dave and others.

January 25/05 - All indications confirm Dave's excellent health. The oncologist remarked that the MRI showed the former tumor site is "even better than before."


Please note:

What is discussed here is very advanced nutritional science --Glycobiology. Understandably, it is rapidly becoming obvious that it is the hope of modern health care. MIT (Massachusetts Institute of Technology) thoroughly examined it and has publicly affirmed that this approach to wellness will change the entire world as we now know it. However, these are food supplements. They do not diagnose, mitigate or cure any disease, but supply the body with vital, missing nutrients so that the body can heal and care for itself. They do not replace the care of a physician.

For more information, contact the person who gave you this.

Thanks for your time. Feel free to contact Deborah and me.
 

Sincerely,

David Eastman

8721 Birnam Line (RR #1)

Arkona, ON, Canada N0M 1B0

January, 2005

* Glyconutritionals are nutrients that are science-based. They make up (supplement) nutrients missing from the modern diet. They are vitally important with a proven track record of supporting wellness in outstanding ways. My experience is a classic example of that.

Note:

The 12 month update on David Eastman was about the same, his health is good and not trace of the tumor or cancer has been found in his body.

 

Friday, February 04, 2005

 

Biochemistry and Molecular Biology

Note:

The OU School of Medicine puts out a publication twice a year and it is sent to alumni and friends of the OU School of Medicine. This is a copy of the most recent article, Fall of 2004.


How Sweet It is!

 

Move over genomics. Out of the way, proteomics. Make room for glycomics, the third leg of the race to understand the body's most basic mechanisms.


Glycomics may not yet have the notoriety of its scientific siblings, but the international effort to identify, catalog and understand the staggeringly complicated assemblages of sugar molecules decorating the body's cells may wind up being the most difficult - if not the most important - challenge of all.

Where there are "only" about 30,000 human genes, there are likely far more then 30 million complex carbohydrates structures. As science is now discovering, each may have its own critical biological function far beyond the long-held view that their primary purpose were for energy storage (as glycogen) or structural (as in connective tissue, fluid in the eye or the exoskeletons of insects and shellfish).
 

Only in recent years has the idea been widely accepted that chemical messages between cells are encoded within complex carbohydrates. These are large molecules of complex carbohydrates. These are the large molecules of sugars, assembled in strings and branches like elaborate pendants, which are attached to proteins and lipids. In other words, when cells communicate chemically with each other about everything that happens in our bodies, from making new tissues to fighting infection, they often say it with sugar.

Leaders in the international effort to create a "library" of the intricate and often transitory structures and to understand their function are a determined group of OU College of medicine biochemists. What these scientists have already learned may hold the keys to keeping cancer at bay, solving the mysteries of auto immune disease, battling disease, healing wounds and even easing the aches and pains of aging.
 

By foresight and fortunate happenstance, the Department of Biochemistry and Molecular Biology chaired by Paul Weigel Ph.D., has achieved a "critical mass" of faculty glycobiologists ("glyco" = sugar) just as the relevance of complex carbohydrates in the development of new therapies has at last been recognized.

Not that there was much chance that glycobiology would be considered irrelevant in Weigel's department. Since coming to the OU college of medicine a decade ago, with the mandate and resources to build the department, he's either hired or trained one of the largest and best-funded contingents of glycobiologists in the nation - second in size only to that of the University of California at San Diego.

First Weigel and then others joined Richard D. Cummings Ph.D., an internationally recognized pioneer in the field. Cummings is a George lynn Cross Research Professor, holder of the Ed Miller Endowed Chair in Molecular Biology and self-described "Johnny Appleseed" for spreading the word about glycomics. Cummings came to OU in 1992.

The "critical mass" of OU glycobiologists and their army of research assistants have been responsible for more than 100 patents in the past decade. Several biotech companies located at Presbyterian Health Foundation Research Park have sprung from this research, not to mention major breakthroughs in identifying some of the key roles played by carbohydrates.
 

For example, Cummings and his research assistant professor, Tongzhong Ju, M.D., Ph. D., in collaboration with Lijun Xia, M.D., Ph.D., and Roger EcEver, MD., at the Oklahoma Medical Research Foundation, found that mice engineered to lack the T-synthases gene are unable to grow new blood vessels through the process called angiogenesis. This was the first know indication that the addition of sugars to proteins regulated such fundamental process as angiogenesis. It stimulated enormous excitement at the prospect of finding a way to keep cancerous tumors from causing formation of blood vessels that sustain their growth.


In another first, Cummings and Ju discovered that some tumor cells carry a mutation with a gene that regulates the creation of glycoproteins, which, in turn, regulate cell growth. Cummings speculates that this gene, which he an Ju have dubbed Cosmic, mutates spontaneously early in the life of the tumor.
 

The mutation of the Cosmc gene leads to altered glycoproteins possibly improved survivability of cancer cells and even the enhanced ability to metastasize. These altered carbohydrate structures have been found in breast, colon, gastric, ovarian and liver cancer.

In 1999, Cummings, Weigel, their faculty colleagues and several others outside the department - "those of us excited and interested in glycobiology" - funded the Oklahoma Center for Medical Glycobiology in the Stantion L. Young Biomedical Research Center building on campus. Cummings is the center's director.
 

Their goals for promoting research in this under-appreciated field of science were ambitious. They wanted to be able to provide technical assistance to all researchers in the field, foster professional collaborations and respond to request for help from any clinical or scientist who wanted to know more.

They also wanted to be among those who would move the field forward.

"Paul Weigel and I decided that through this center, we'd be able to complete with the giant universities and research institutions like MIT and Scripps Research Institute, "Cummings recalls. They were right.
 

With sophisticated equipment purchased with grants form the Presbyterian Health Foundation and funding obtained by the growing glycobiology faculty, the center found itself perfectly placed in the fall of 2001 when the National Institutes of Health pledged $34 million over five years to help scientists understand the role of interactions between carbohydrates and proteins in cell-to-cell communication.

This NIH "glue grant" project is called the Consortium for Functional Glycomics. Because progress in determining the functions of carbohydrates has been slow, the consortium promised to change that by bringing together a large group of scientist from leading academic medical centers across the country.

Cummings is a member of the consortium steering committee, and the Oklahoma Center for Medical Glycobiology is home to two of the seven "core" laboratories participating in the consortium. (see below)

AT THE CORE
 

The OU College of Medicine is home to two of the seven labs participating in the NIH-Funded efforts to identify the millions of carbohydrate structures in the human body and discover their functions.

The Core C sequencing lab uses mass spectrometry and other methods to reveal the structure and chemical properties of carbohydrate molecules for the various animal tissues in which they are found. OU researchers share this task with scientists at the Imperial College of London. Mass spectrometry allows scientists to detect compounds at unimaginably minute levels.

In Core H, researcher dot what's called a "glycan array" with little "spots" of identified carbohydrate structures. This array of spots is incubated with extracts of human or animal tissue or purified proteins to identify the carbohydrate binding proteins and determine which carbohydrate compounds they recognize. Using this technique, Core H identifies samples for scientist around the world.

The work is an exciting as it is daunting. As Cummings says with barely contained delight, "We haven't even found the tip of the iceberg."
 

MIT calls glycomics one of the 10 emerging technologies "that will change the world."

Weigel, a George Lynn Cross Research Professor, has been working for decades to ferret out the role of complex carbohydrates.
 

He says there's a "straightforward" reason why science is suddenly so interested in these molecules, and it has everything to do with the dawning realization of their biomedical importance. "All but one of the molecules that are outside the cell contain carbohydrates, whether there in blood, the lymph, the matrix, stuck between cells or on the surface of cells. Every protein with potential for therapeutic use whether it's a hormone or an antibody, is a glycoprotein", he says.


"The hold-up has been that it's technically much, much more difficult to study carbohydrate structures than to study proteins or DNA," Weigel said. Unlike proteins which are produced by an individual gene and are linear in structure, carbohydrates form intricate three dimensional structures from a cascade of chemical instructions.

"Of we could figure out all the (sugar) structures in my body and your body, then at least we'd have a library, just as we now know all of the genes in a genome. We'd be able to ask, 'What does this one do?' 'Where is it?' Is it important?' 'Is it involved in cancer?' 'Is it involved in something that is bad in terms of blood vessels, for example?"

Teasing out the answers isn't easy for a number of reasons. Sugar molecules combine, branch and dangle in a seemingly infinite number of ways, making cataloging the shape alone a daunting task. There is also the challenge of identifying those proteins that "turn on" the production of all these structures and the ones that turn them off.

Once sugar structures are identified, "you can start to ask what they are and what they are doing.," Weigel said.
 

Weigel has been asking these questions for years, and lately in collaboration with faculty colleague Paul DeAngelis Ph.D., has made some significant breakthroughs. These discoveries involve some very complex sugar structures and some very tiny bugs in making life easier for Baby Boomers and for everyone who undergoes surgery.
 

The first sugar structure is the polymer Hyaluronic acid (or HA), a viscous substance that lubricates your joints and keep your eyeballs full and round. The second is heparin, an anticoagulant whose use is ubiquitous in modern hospitals. Third is chondroitin, important for fighting osteoarthritis. When your body needs any of these three substance, therapeutics made from cow and pig parts and even from shark fin are currently available. However, when pharmaceutical companies look to new sources, the bugs and glycobiology enter the picture.

The bugs are certain Streptococcus and Pasteurella bacteria able to camouflage themselves with coatings of carbohydrate molecules. These coatings keep them from being detected by their hosts' immune system. Weigel and DeAngelis have discovered enzymes that catalyze the sugar-building process for HA, heparin and chondroitin.

The results: bacteria that mass-produce the three types of sugar chains needed to manufacture medical devices and therapeutics.

"It's been fun trying to figure out how this works, "DeAngelis said. "Typically, when the bug makes molecular camouflage, it's making chains that are thousands of sugars long."

These long chains and the thousands of permutations possible in sugar structures are what make glycobiology such a challenge. They are also what makes the discoveries in the field so important.
 

For example, long sugar chains of HA are important in eye surgery, but it now appears that very small fragments of the NA came make cancer cells committee apoptosis or suicide. The challenge has been to coax sugar chains that link up in the right sizes. The OU scientists have found a solution. "We've found a way that tames the catalyst into making small sugar chains that have anti-cancer activity." DeAngelis said "it turns out that around 12 to 20 sugars is the sweet area for making the cancer cell say, 'Oops, I'm going to commit suicide.'" Using new mutant versions of the Pasteurella enzyme, DeAngelis can build molecules one sugar at a time until the suicide-causing size has been reached.

"It's an emerging area, but it looks like cancer cells like having the big' HA (chains) around because it apparently tells the cell to keep dividing. But if you put in small sugars, the signal doesn't occur."

Another recent discovery that new blood vessels will sprout on instructions from "small" HA is just another in an endless stream of discoveries expected to arise as OU biomedical scientist carve out new territory in the exciting area of glycobiology.

Note: The options of this article may or may not be held by the owner of this website. Glycoproteins nor any other nutritional component are intended to treat, cure or heal any ailment or disease condition. We can not be held responsible for the beliefs expressed by the authors in the articles on this site.
 


 

Thursday, January 27, 2005

 

Glycomics - There are 2 Sides to EVERY Story

There are two sides to every story when it comes to Glycomics:

Side one - "My doctor has never hear or told me about this so it must not be that important!"

Side two - MIT calls glycomics one of the 10 emerging technologies "that will change the world."

Which side do you prefer?

Also, Paul Weigel, PhD., from OU university (University of Oklahoma), a George Lynn Cross Research Professor, has been working for decades to ferret out the role of complex carbohydrates. He says there's a "straightforward" reason why science is suddenly so interested in these molecules, and it has everything to do with the dawning realization of their biomedical importance.

"All but one of the molecules that are outside the cell contain carbohydrates, whether there in blood, the lymph, the matrix, stuck between cells or on the surface of cells. Every protein with potential for therapeutic use whether it's a hormone or an antibody, is a glycoprotein", he says.

Now when you read this article you can decide for yourself how important this new cutting edge science is to your health and your wealth.

Best Regards

Ed B. RN MS

 

Wednesday, January 26, 2005

The New Nutrition Paradigm

by Rayburne W Goen, MD, FACP, FACC.

December 21, 2001

 

The New Nutrition and Doubting Doctors

Dear Doctor:

Thank you for allowing me this opportunity to introduce you to a monumental discovery in Healthcare, only recently acknowledged (1996) in Medical Journals and Textbooks.

When I first heard about Glyconutritients 2-1/2 years ago, I called it "Hogwash", and declared anyone who claimed that oral administration of these supplements was of striking benefit to people suffering from a long list of unrelated diseases or ailments was a QUACK! In the same class as all the others making such claims for relief of a multitude of ailments, whatever the modality, so blatantly proclaimed and touted in numerous brochures and catalogs in the daily mail. I was closed-minded-- call it skeptical, dubious, or cynical- as you and the rest of our Medical profession would have been, and are. I was, however, receptive enough to read the pertinent Medical Journals supplied to me, and I must admit I was a little jarred at the implications of what I read. I began to look into what turned out to be an overwhelming amount of related literature: Carbohydrate Metabolism is suddenly a hot subject--over 20,000 papers in Medline 1996-1998, and an equal number since. Most of them are in specialty Research Journals that we as practicing physicians do not take or read- nor readily understand! The Clinical articles published thus far have been mainly retrospective: case reports of a series of patients with a major disease, and with suspiciously high percentages of positive results. I read many of these articles, but I could not believe they could be documenting something so fundamentally powerful, as that a mere food supplement could correct a deficiency in our diet so vitally important as to be the mechanism of all cellular communication in our body!

I was already well versed in that kind of hype! I had previously tried, on myself, enthusiastically at first, the highly touted Glucosamine, Chondroitin Sulfate, Cetyl Myristoleate, MSM, SAM-e, Blue Green Algae, Alfalfa Tea, Olive Leaf Extract, Colloidal Silver: -- each with lots of “ink” but not one helped me in any way. I proposed to try (surreptitiously-“don’t tell anybody”) Glyconutrients for a list of 21 ailments I could identify in myself, rated in severity from 1-10, attributable mostly to "old age" (I was 85 years old at the time). I was not neurotic-- just trying to be scientific. None of these completely disabled me, except Arthritis of knees, which required aspiration of fluid and instillation of a Cortisone, Depo Medrol, more and more frequently, eventually about every 3 months for one, then the other knee.Then I would again be functional; and I had a Peripheral Neuropathy which impaired my balance and walking, and sleep because of restless legs. Within 4 months, I became symptom-free of 20 of these 21 complaints: the two mentioned, and a right shoulder rotator cuff tear, low back pain, cervical disc with left C-5 radiculopathy, inflammatory osteoarthritis of hands (I could not shake hands without hurting the next 3 days), hypertension (190/105), hypercholesterolemia (320mg) since in my 30’s, nocturia 4-6x per night, urinary urgency incontinence, prostate cancer, developing cataract left eye, etc. I was able to discontinue all the 6 prescribed drugs, and all over-the-counter, except 1 aspirin every other day (I had a Coronary in 1990, after which I began this). The drugs had been effective to a degree, but all had side effects that were either disagreeable or intolerable.

That result was not enough to convince me. This had to be some sort of “fluke”!

I resolved I could disprove this “stuff” by persuading a “know-it-all” relative who scoffed at the idea of taking supplements like these for his refractory Raynaud's Syndrome (cold-sensitive fingers that turned purple and agonizingly painful upon exposure); uncontrolled Diabetes type 2 with serious adverse effects from Insulin and oral anti-diabetes drugs; Hypercholesterolemia and Diabetic Peripheral Neuropathy, worsened by all “statin” drugs for cholesterol reduction. He was scheduled for replacement surgery of both knees, each of which had been operated twice for old injuries and loss of cartilage, poorly responding to NSAID drugs, and with intolerable side effects.

He had stated he was going to discontinue all the above drugs--- he had rather died than live this miserably. I reminded him that dying is an easy out, but that he might not die, but be disabled by Heart Attack, Stroke, Amputations, or Renal failure and Dialysis. I managed to induce him to try Glyconutritionals for 4 months, with the assurance they absolutely could not harm him. He reluctantly agreed...Three weeks later he reported he was free of pain and paresthesias, was having normalized blood sugars on just the one oral anti-diabetes drug he had continued (but that previously had not controlled the high blood sugar) His vision and mental clarity were strikingly improved. He neglected, however, to reorder the supplements, and the symptoms all recurred within 2 weeks. Upon resumption of the supplements, the symptoms again abated. Koch’s postulates fulfilled!!

I still was not convinced! I did cautiously offer Glyconutrients to several other former patients, including 2 refractory diabetics with complications, with similar salutary effects. I was nearly convinced after almost a year of results that I could only describe as incredible!

So---- I gave Glyconutritionals to Zondra, a patient whom I had “doctored” for 50 years with Muscular Dystrophy, Spinal Atrophy type. (Her brother had died at age 13 with Duchenne type MD). She was total care since age 2 years; unable to do anything for herself; had impairment of swallowing; and was on Oxygen 24 hours daily. She was able to do some ceramics painting, with her right arm supported on a table, for 2 hours, twice a week. 4 months after starting glyconutrients, she could, for the first time in 50 years, feed herself, brush her teeth, scratch her nose, and is now off Oxygen for 3-4 hours daily. She can now swallow well, and she can paint 6-8 hours per day, 6 days a week! She states “I have so much energy I could do more, but know I should rest some, whether I feel the need or not!” She has sustained this improvement, and for the first time ever she has not been treated or hospitalized for respiratory failure or infection in over a year, despite a Flu epidemic disabling two of her Nurses and her room mate!

Bill, a former Surgical Technician in the Service, developed Type 2 Diabetes after returning from overseas in the 80’s. When originally diagnosed, his blood sugars were in the 900’s and remained uncontrollably high (above 500) for many years, despite multiple injections of regular Insulin up to 200 units daily, plus Ultra-Lente (long acting) Insulin 120 Units daily. He exhibited Retinopathy, with bleeding inside both eyes requiring years of Laser cautery therapy every 3 months, which provided some improvement but could not prevent subsequent recurrences. He developed Peripheral Neuropathy of both legs and arms with complications of Diabetic Ulcers on his legs and feet, for which amputation was advised. This he refused, but searched the internet to find a possible relief. He experienced considerable muscle deterioration, with Claudication (leg cramps) and Angina on attempting to walk half a block. He gained weight, up to 330 lbs, with the inactivity. Despite being on multiple anti-hypertension medications, his blood pressure for years averaged 200/115. He developed arthritis, with difficulty doing anything with his hands. After 4 years, and requests from a Podiatrist, his Physical Therapists, a Neurologist, and a Health South Rehab Doctor, he finally obtained HMO authorization for an electrified “scooter” which enabled him to get up and around… In the early 90’s, over a 3-4 months time period, he had a series of strokes and 3 TIA’s. He was diagnosed Sleep Apnea, complicated by shortness of breath at rest, necessitating 6 assorted inhalers, including nasal and tracheo-bronchial steroids. He experienced heart failure with edema of the lower limbs. The strokes left him with some permanent left-sided weakness, migraine headaches, and double vision. For years he has been on a multiplicity of antibiotics - a month without any was considered a “Good Month”! His Kidneys began to excrete albumin, and his BUN and Creatinine elevated as he approached renal failure that would require Dialysis. Because of the seriousness of his combined health problems, he “believed this would prove TERMINAL in a short period of time”. He became severely depressed because of his condition, and by what it was doing to his family. Despite what he could find on the Internet, and despite the efforts of 12 Doctors and Specialists, nothing seemed able to alter the downward trend of his health.

He had “given up ALL HOPE, and was making preparations for his funeral”, when he was introduced to Glyconutritionals. After some Internet research he decided as a last resort to try some - “not expecting “ANYTHING” to happen . After all, nothing else had helped”. 3 months later the vision was improving, the ulcers of feet and legs were healed, the pain, swelling, weakness (including the left side stroke weakness), shortness of breath, and angina no longer were a problem.

He was off all 6 inhalers, including steroids, and his arthritis was all but gone. He is able to walk without depending on the scooter or a cane. The Migraine has resolved, as has a chronic sinusitis, and he has not needed any more antibiotics. Blood pressure now averages 130/85 The albumin is no longer found in his urine, and the creatinine levels have not increased, indicating stable renal function rather than the previously noted progression. He lost to 280 lbs weight, and continues to lose fat and regain muscle mass. . The Insulin has been reduced to 10-50 units daily of Regular, with Ultra-Lente 60 units each Am and PM . The blood sugars are running 105-125, and the Glycohemoglobin (A1c) is now an incredibly low 5.1 (a measure of the biological level of glucose saturation of the Red Blood Cells. Very, very good!) He has admittedly not paid enough attention to his diet, and could no doubt reduce his weight and Insulin further by following a low glycemic diet, and, now that he is able, he is starting to do more exercise. His severe depression is no more, and best of all, to quote him, “I NOW HAVE HOPE, WHERE THERE WAS NONE! I am amazed at the changes that are occurring-some fast, some slow, some not yet, but things ARE IMPROVING!”

Maxine is a 65 year old housewife who had Breast Cancer in 1984, treated with bilateral mastectomy. The cancer recurred in the abdomen and stomach 13 years later, for which she received 6 chemotherapy treatments in 1997. These were very poorly tolerated, and did not improve her condition. She developed obstruction of colon, necessitating a colostomy; and blockage in the stomach resulting in abdominal swelling, loss of appetite, and rapid weight loss. She was told there was nothing more to do, and Hospice was utilized for pain control with injections of narcotics, with expectation of death within 6 months. 3 months passed, with a downhill course. She and her husband did not give up, and sought help from herbs and whatever anyone might recommend, but without benefit.

Glyconutrients were offered to her, and in desperation she began to take them. Within 2 weeks she was out of bed, going to Church, and a week later she insisted on going to a garage sale! She is now up and around, doing housework and the cooking, enjoying eating, in little pain, and the abdominal swelling has disappeared. Praise God!

Such RESULTS as these, and now many others, I have not seen before in my 60 years as a Doctor!! Glyconutrients are fully documented to be safe, non-toxic, do not interfere with Rx drugs, and they work! Admittedly, no one thing is 100% - there must yet be some more unknown essentials, as well as the other known essentials: oxygen, water, and food: amino acids, fatty acids, carbohydrates, vitamins, minerals, trace elements. None of those are now apparently deficient within our current diet and traditional supplements - except 6 of the newly-recognized 8 essential monosaccharides!

The only things that convince most of us Doctors are CONSISTENT, SAFE, RESULTS. We have all been led down the primrose path with promising new drugs, approved by the FDA, and seen them withdrawn from the market 6 months later because of dire effects on the liver, kidneys, bone marrow, GI tract, and/or pregnancy. How many more do we daily prescribe which result in only occasional "idiosyncratic" lethal effects with approved doses within the acceptable risk-benefit ratio? (but over 106,000 in the year 1997 died in hospitals from reactions to properly prescribed and taken drugs, as reported in JAMA July 26, 2000. This is the fourth leading cause of death in the US, outnumbered only by: Heart Attacks, Cancer, and Diabetes). It has happened in my practice, as it has in yours and every other Doctor who prescribes for patients. It has been devastating enough to me and you, but how much more so to the patients and their families! For them it is 100%!

Carbohydrates were always acknowledged to be just for energy. Not any more!! Of the 200 known simple saccharides), there are 8 now recognized to be essential to all cellular function. They are glucose, galactose, mannose, xylose, fucose (not fructose), N-acetylneuraminic acid (also called sialic acid), N-acetylglucosamine, N-acetylgalactosamine. Six of these “eight essential monosaccharides” are universally lacking in our diet, because of soil depletion, green harvesting, processing, preservatives, and overcooking. Fortunately our bodies can make the other 6 from glucose and galactose, if everything is all right! Obviously, everything is not all right if the body has a Health Problem, whether from infections; toxins in our environment: the air we breathe, the food we eat, the water we drink; stresses in our lifestyle; deficiency of a necessary enzyme, vitamin, co-factor, trace mineral; or a genetic defect, in the 15 or more stages, plus much energy, to convert one (available) sugar to another! Currently, the most important one of all these “essentials” is the one that is missing! And “essential” means indispensable: without it, the body is dysfunctional, sick or dying!

There are many new studies, Double-Blind, Placebo-Controlled, with enough numbers to be Statistically Significant, as we are so used to seeing, but these are years away from being reported.

Many are not subject to double blinding or placebo control, such as near-terminal Cancer cases, Genetic Disorders with progressive downhill course, and Immune Dysfunction diseases which are epidemic, overwhelming us over the past 2-3 decades, and for which we have no cure --- nor even satisfactory or safe relief of the symptoms, with our conventional therapy. Asthma, Lupus, Hepatitis C, Rheumatoid Arthritis, Osteoarthritis; Cancer, ADD-ADHD, Fibromyalgia, Diabetes types I and II, Chronic Fatigue Syndrome, Multiple Sclerosis, AIDS, Ulcerative Colitis, Crohn’s Disease, Down Syndrome, Muscular Dystrophy , ALS (Lou Gehrig’s Disease), are just a few examples.

Administration of Glyconutrients has resulted in improvement or remission, without any harmful side effects, in each of these conditions, as documented in reports or publication in peer-reviewed Medical Journals. What could possibly be the common denominator of all these? Immune System Dysfunction! Why? Something is missing!

Glyconutrients are not a treatment, mitigation, or cure for any disease, but if these food supplements are supplied in the diet, the body can heal itself of virtually anything wrong! (But not grow a new tooth in an adult if one is pulled, nor a new limb if it is amputated. That is not in our DNA! It is, however, in the DNA of Earthworms cut in half, Sharks who lose a tooth, and Centipedes who lose a leg!

These 8 monosaccharides are in and on the surface of every cell in the body. They are necessary as the glyco of glycoproteins on the surface of every cell, as transmitter or receptor, of all the vital reactions between cells: defense, repair, regulation, nutrition, and apoptosis, (the programmed death and recycling of all cells). Every cell in the body (100 Trillion or so!) is replaced at different rates: (e.g. WBC, 6-7 days; RBC's, 3-4 months; DNA and most Internal Organs, 6 months; Bone, 9 months to years; Brain and CNS, 14 months). These monosaccharides are present as a substrate in the endoplasmic reticulum, and as building blocks for the glycosolation occurring in the Golgi apparatus of cells, forming glycoproteins, proteoglycans, glycolipids, and the N- and O- and GPI- anchored linkages (Nitrogen- ,Oxygen-, and Glycosylphosphatidyl-inositol- linkages). This is all under control of the DNA as the blueprint, and mRNA, as the message. The glycoproteins translate the messages and send chemical signals (cytokines) to the appropriate receptors, (also glycoproteins) to facilitate the proper action at the cellular level. This is the Universal Code of Life, equivalent to the Microsoft Operating System, which runs all computers! This is extremely complicated and has to be, not 99.9999% perfect, but 100%, or there is dysfunction, disease, or death! I have studied it intensively, still know so little, but yet enough to be awed and excited by what I have witnessed! Supplying Glyconutritionals in the diet has enabled the body to modulate the immune system: elevate those elements that are too low, as in Cancer and AIDS; reduce those that are too high, as in autoimmune diseases; or do both, as in most of the immune dysfunctions!!

This Modulation had been considered impossible-something never before seen in Medicine. The Natural Killer Cells, necessary as the first line of defense against Infection and Cancer, are reduced by 30 % in even the “normal” population in the past 2 decades, and are further falling by 3% per year. No wonder 250,000,000 of the US population are suffering from some form of acute or chronic disease! These NKcells are restored to normal numbers in those receiving Glyconutrients. How? I do not know! But the body knows! Thank God!

Dr. Robert K Murray, Senior Editor of Harper's Biochemistry (Appleton and Lange,1996) wrote the chapters 56 through 65 on: Glycoproteins; The 8 Essential Monosaccharides; The Extracellular Matrix; Muscle Metabolism; The Immune System; etc. I now have the 2001 revision, and am poring over the awesome biochemical reactions, newly-discovered, in this explosively growing segment of Biochemistry: Glycoscience, Glycobiology, and Glycomics! I will ask you, Doctor, if I may, "How did you advertise when you started your Medical Practice? Newspaper? Radio? TV?" "Or Word of Mouth from satisfied Patients?? I can guess!!! So did I! Don't knock Word of Mouth! We do not sell products, but educate and introduce the good news to those we love and want to help, who then can order these Glyconutrients wholesale from the only company who can supply all of them, have them shipped directly to their home; to be taken as a complement to conventional Medical Care. We and they see benefits more safely, more completely, more consistently, and less expensively, than we have ever seen in our lives before! And they, in turn, will share the good news with others who are suffering from the effects of these deficiencies!

I am now retired, but I can’t deny my love for Medicine, nor yet ignore the recent monumental advancements in the Science of Nutrition, and especially the role of monosaccharides in the formation of glycoproteins, so vital in the function of the cells of our body. At age 87 I am starting a new career (nay, Mission!) to share with everyone I meet, this epochal Nutritional Breakthrough, and its effect on the immune function. Medicine has advanced beyond the Blood-letting, Leeches, and Maggots treatment of disease to Immunizations, Wonder Drugs, incredible Surgery, Organ Transplants, and Genomes. We have great expectations from the latter, but the promised wondrous cures are yet years away from application, and even the initial Genetic modifications are fraught with the same old side-effect complications as other synthetics have exhibited. The body is programmed by God to utilize whatever it needs from our diet, and is not about to change. Stem Cell Cloning is far from perfect, although it must be invariably perfect, and subject to the same responses to nutritional deficiencies as those we have found so refractory-until the missing Glyconutrients are supplied. Glyconutrients are already available here and now, safe and effective, awaiting but the eventual universal recognition by all Health Professionals: that this New Nutrition is the Keystone of Prevention and Wellness, as our New Focus in the Practice of Medicine, versus the traditional paradigm of Treating Sickness with Drugs).

This new Paradigm in Medicine did not originate in the traditional “A Drug Cure for Every Disease” concept of Pharmacology, nor yet by the Nutritionists. This is a “Disruptive Technology”, comparable to the displacement of wax and vinyl phonograph records with magnetic tape, and this in turn by digital CD, each of which was birthed by a totally unrelated industry. Likewise, was the obsolescence of the watch and clock by the quartz crystal; and the mechanical typewriter by the electric, and this, in turn, by the word processor of the computer, again an upstart industry.

The new Biochemistry: Glycobiology, Glycoscience, Glycomics: Glyconutrients!

For those who might be interested in my “pedigree”, I have BA and MD degrees (1939) University of Colorado: (Phi Beta Kappa, and Alpha Omega Alpha, Honor Medical Society). Lt. Col. Medical Corps. Army of US, WW II; Diplomate American Board of Internal Medicine; Fellow American College of Physicians (FACP); Fellow American of College Cardiology (FACC); Clinical Associate Professor of Medicine, University of Oklahoma School of Medicine, Tulsa; Past Chairman Medical Section, St John Medical Center and of St. Francis Hospital; past Vice-President Medical Staff St. John Hospital; past President Medical Staff St. Francis Hospital.

I couldn’t blame you if you thought me a Kook,--- but do please be open-minded, for your own sake, and for that of all your patients. And in so doing you will honor the aphorism of that wise old Doctor, Hippocrates, the Father of Medicine, whose first concern with his patients was “Primum non nocere.” Above all, do no harm! And his next was “Let your food be your medicine, and let your Medicine be your food.”

What goes around comes around!

Rayburne W. Goen, Sr. MD
 

Note: These saccharides are not intended to heal, treat, or cure any disease.
 

Tuesday, January 25, 2005

 

Note: Glyconutrients are not intended to heal, treat, or cure any disease.